TWS119

SKU: orb1306251

Description

TWS119 is a selective inhibitor of glycogen synthase kinase-3 beta (GSK-3β). Its application in research includes promoting neuronal differentiation in vitro and has been investigated in studies of neurogenesis and neuronal development.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 601514-19-6
• MW: 318.33
• Purity: 99.63% (May vary between batches)
• Formula: C₁₈H₁₄N₄O₂
• SMILES: Nc1cccc(c1)-c1cc2c(Oc3cccc(O)c3)ncnc2[nH]1
• Target: GSK-3,Autophagy,Wnt/beta-catenin
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.28 mM);DMSO:60 mg/mL (188.48 mM)

Bioactivity

• Target IC50:
  GSK-3β:30 nM
• In Vivo:
  A cell population that expressed low levels of CD44 and high levels of CD62L on the cell surface when 30 mg/kg of TWS119 is administered.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, Glycogen synthase kinase-3, Glycogen synthase kinase 3, GSK-3, GSK3, GSK-3β, Inhibitor, TWS119, TWS-119, TWS 119

Compound Identifiers

PubChem CID

9549289