TUG-891

SKU: orb1304206

Description

TUG-891 is a G protein-coupled receptor (GPCR) activated by long-chain fatty acids, with expression noted in intestinal tissue, adipocytes, and pro-inflammatory macrophages. It serves as a research tool for studying metabolic inflammation, fatty acid signaling, and immune cell function in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1374516-07-0
• MW: 364.41
• Purity: 99.21% (May vary between batches)
• Formula: C₂₃H₂₁FO₃
• SMILES: C(OC1=CC=C(CCC(O)=O)C=C1)C2=C(C=CC(F)=C2)C3=CC=C(C)C=C3
• Target: GPCR
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:40 mg/mL (109.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.49 mM)

Bioactivity

• In Vitro:
  TUG-891 exhibits analogous signaling characteristics to the long-chain fatty acid (LCFA) α-linolenic acid at the human Free Fatty Acid receptor 4 (FFA4), stimulating Ca2+ mobilization, recruiting β-arrestin-1 and β-arrestin-2, and promoting extracellular signal-regulated kinase phosphorylation. Moreover, TUG-891 activation of FFA4 leads to the receptor's swift phosphorylation and internalization.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, FFAR, Free Fatty Acid Receptor, GPR120, TUG 891, TUG891, TUG-891

Compound Identifiers

PubChem CID

57522038