TUG-891

SKU: orb1223329

Description

TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.

Key Properties

• CAS Number: 1374516-07-0
• MW: 364.41
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₁FO₃
• SMILES: c1(c(ccc(c1)F)c1ccc(cc1)C)COc1ccc(cc1)CCC(=O)O
• Target: Kinesin
• Solubility: DMSO : ≥ 180 mg/mL 493.95 mM

Bioactivity

• In Vitro:
  TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TUG-891 | TUG 891 | TUG891

Quick Database Links

Gene Symbol

Kinesin