Tubercidin

SKU: orb1300150

Description

Tubercidin

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 69-33-0
• MW: 266.25
• Purity: 99.83%
• Formula: C₁₁H₁₄N₄O₄
• SMILES: Nc1ncnc2n(ccc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
• Target: Antibiotic,Influenza Virus,DNA/RNA Synthesis,Antibacterial
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (206.57 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.51 mM)

Bioactivity

• In Vivo:
  Tubercidin a the dose regimen (5 mg/kg everyday for 4 days) is lethal when used alone. Some o the studies show tha the mortality from tubercidin is primarily due to hepatic and renal injuries and to a lesser extent, damage to the pancreas. Coadministration of NBMPR-P at 25 mg/kg per day completely protect the mice (100% survival) from this lethal dose regimen of tubercidi.
• In Vitro:
  Continuous exposure for 14 days to tubercidin alone is highly toxic to both human CFU-GM and BFU-E the IC50 of tubercidin are 3. ± .7 and 3. ± .2 nM for CFU-GM and BFU-E, respectively Tubercidin also has a Direct dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells in vitr.
• Cell Research:
  Human bone marrow cells were obtained from healthy volunteers. in the protection studies, cells are exposed to 10 nM of tubercidin in the presence or absence of various doses of NBMPR-P. Cells are continuously exposed to drugs for 14 days in a humidified atmosphere of 5% C02-95% air at 37°C. Colonies of CFU-GM (250 cells) and BFU-E (>30 hemoglobinized cells) are counted with an inverted microscope. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Sparsomycin A, Tubercidin, RNASynthesis, RNA Synthesis, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, Bacterial, Antibiotic, 7-Deazaadenosine, inhibit, Influenza Virus, InfluenzaVirus, Inhibitor

Compound Identifiers

PubChem CID

6245