Trifluoromethyl-tubercidin

SKU: orb1741445

Description

Trifluoromethyl-tubercidin

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1854086-05-7
• MW: 334.25
• Purity: 99.85% (May vary between batches)
• Formula: C₁₂H₁₃F₃N₄O₄
• SMILES: O[C@H]1[C@H](N2C=3C(C(C(F)(F)F)=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O
• Target: Influenza Virus
• Solubility: DMSO:3.35 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  Trifluoromethyl-tubercidin treatment at 2 days after infection with IAV. At this point, NP and PB2 mRNA levels were significantly reduced by trifluoromethyl-tubercidin treatment in mouse lungs, indicating that the trifluoromethyl substitution of tubercidin reduces in vivo toxicity to levels we could not detect, but retains anti-IAV efficacy.
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• In Vitro:
  The median inhibitory concentration (IC50) for trifluoromethyl-tubercidin against IAV infection was 0.30 μM, and no notable in vitro toxicity was observed in the range of effective concentrations, as measured with water-soluble tetrazolium (WST)–8 cell viability assay. Trifluoromethyl-tubercidin treatment also greatly inhibited IAV replication when administered 3 to 4 hours after infection. Trifluoromethyl-tubercidin showed inhibitory activity in the IAV-infected mouse cell line LA-4, albeit with lower potency (IC50 = 7.7 μM) than in human cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

InfluenzaVirus, Influenza Virus, MTr1(host), Trifluoromethyltubercidin, Trifluoromethyl-tubercidin

Compound Identifiers

PubChem CID

118636125