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TRPV4 agonist-1

SKU: orb1218362

Description

TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).

Research Area

Pharmacology & Drug Discovery; Cell Biology

Images & Validation

Key Properties

CAS Number2314467-60-0
MW484.93
Purity>98% (HPLC)
FormulaC25H23ClF2N4O2
SMILESO=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C1C=CC=C5F.[H]Cl
TargethTRPV4 Ca2+

Bioactivity

In Vitro
TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

TRPV4 agonist-1 (orb1218362)

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200 mg
500 mg
5 mg
$ 1,500.00
50 mg
$ 3,040.00
100 mg
$ 3,830.00