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TRPM8 antagonist 4

SKU: orb3135777

Description

TRPM8 antagonist 4 is a compound with high functional selectivity and favorable physicochemical properties, serving as a CB2R partial agonist (EC50=54.2 μM, Ki=3.2 μM) and a TRPM8 (IC50=42.3 nM) antagonist. It possesses notable anti-inflammatory and analgesic effects, demonstrating good safety by reducing the mRNA expression of TNF-α, IL-6, and IL-1β.

Images & Validation

Key Properties

TargetInterleukin,Cannabinoid Receptor,TNF,TRP/TRPV Channel

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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TRPM8 antagonist 4 (orb3135777)

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