RN-1747

SKU: orb1307788

Description

RN-1747 is a selective TRPV4 channel agonist with EC50 values of 0.77 μM (human), 4.0 μM (mouse), and 4.1 μM (rat), and also acts as a TRPM8 antagonist (IC50: 4 μM). This compound is a valuable research tool for investigating TRP channel physiology in models of pain, osmoregulation, and respiratory function in both cellular and animal studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1024448-59-6
• MW: 395.86
• Purity: 99.34% (May vary between batches)
• Formula: C₁₇H₁₈ClN₃O₄S
• SMILES: [O-][N+](=O)C1=C(C=CC(Cl)=C1)S(=O)(=O)N1CCN(CC2=CC=CC=C2)CC1
• Target: TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.05 mM);DMSO:55 mg/mL (138.94 mM)

Bioactivity

• Target IC50:
  TRPV4 (mouse):4.0 μM(EC50)|TRPV4 (rat):4.1 μM(EC50)|TRPV4 (human):0.77 μM(EC50)|TRPM8:4 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

rTRPV4, RN1747, RN-1747, RN 1747, TRP Channel, TRPChannel, TRPV Channel, TRPM8, TRPVChannel, Transient receptor potential channels, mTRPV4, inhibit, hTRPV4, Inhibitor

Compound Identifiers

PubChem CID

5068295