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Tropisetron

SKU: orb1940390

Description

Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number89565-68-4
MW284.359
Purity>98% (HPLC)
FormulaC17H20N2O2
SMILESCN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12
Target5-HT Receptor

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ICS 205-930 | Tropisetronum | Tropisteron

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Protocol Information

Tropisetron (orb1940390)

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Available Sizes

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10 mg
$ 80.00
25 mg
$ 130.00
50 mg
$ 220.00
100 mg
$ 320.00
500 mg
$ 800.00