Tropisetron hydrochloride

SKU: orb1309520

Description

Tropisetron HCl is the salt form of a selective 5-HT3 receptor antagonist used to prevent nausea and vomiting. It is widely applied in research involving chemotherapy-induced emesis, both in vitro receptor binding studies and in vivo animal models of antiemetic efficacy.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 105826-92-4
• MW: 320.82
• Purity: 99.65%
• Formula: C₁₇H₂₁ClN₂O₂
• SMILES: Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12
• Target: AChR,5-HT Receptor
• Solubility: H2O:50 mg/mL (155.85 mM);DMSO:6.25 mg/mL (19.48 mM)

Bioactivity

• Target IC50:
  5-HT3 receptor:70.1 ± 0.9 nM
• In Vivo:
  Tropisetron (1 mg/kg i.p.) significantly improves the deficient inhibitory processing of the P20-N40 auditory evoked potential in DBA/2 mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, ICS 205-930, Inhibitor, 5HTReceptor, 5-HT, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT Receptor, Tropisetron, Tropisetron HCl, Tropisetron Hydrochloride, Tropisetron hydrochloride, SDZ-ICS 930, SDZ-ICS930, SDZ-ICS-930, Serotonin Receptor

Compound Identifiers

PubChem CID

656664