Trimethobenzamide hydrochloride

SKU: orb1302191

Description

Trimethobenzamide hydrochloride

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 554-92-7
• MW: 424.92
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₂₉ClN₂O₅
• SMILES: Cl.COc1cc(cc(OC)c1OC)C(=O)NCc1ccc(OCCN(C)C)cc1
• Target: Influenza Virus,Dopamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.41 mM);DMSO:100 mg/mL (235.34 mM)

Bioactivity

• In Vivo:
  Trimethobenzamide exhibits an oral bioavailability ranging from 60% to 100%, with a peak time of approximately 45 minutes post-oral administration. When administered intramuscularly (I.M.), the peak time is around 30 minutes.
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• In Vitro:
  Trimethobenzamide, a (non-phenothiazine) benzamide antiemetic, centrally blocks D2 receptors, inhibiting the medullary chemoreceptor trigger zone by obstructing emetic impulses to the vomiting center.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Influenza Virus, InfluenzaVirus, inhibit, DopamineReceptor, Dopamine, Dopamine Receptor, D2, Ro 2-9578, Tribenzagan Hydrochloride, Trimethobenzamide, Trimethobenzamide hydrochloride, Trimethobenzamide Hydrochloride

Compound Identifiers

PubChem CID

68385