Trimethobenzamide hydrochloride

SKU: orb1221288

Description

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.(In Vitro):Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center.(In Vivo):The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 554-92-7
• MW: 424.92
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₉ClN₂O₅
• SMILES: Cl.COc1cc(cc(OC)c1OC)C(=O)NCc1ccc(OCCN(C)C)cc1
• Target: Dopamine Receptor
• Solubility: DMSO:≥100 mg/mL (235.34 mM)

Bioactivity

• In Vivo:
  The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I. M.) administration about 30 minutes after intramuscular administration.
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• In Vitro:
  Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 2-9578 | Tribenzagan Hydrochloride

Quick Database Links

Gene Symbol

Dopamine Receptor