Trimebutine maleate

SKU: orb1225254

Description

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

Key Properties

• CAS Number: 34140-59-5
• MW: 503.55
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₃NO₉
• SMILES: O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2.O=C(O)/C=C\C(O)=O
• Target: Calcium Channel
• Solubility: DMSO: 38mg/mL

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: A2780-SP cells. Concentration: 1 μM, 10 μM, 20 μM. Incubation time: 60 h. Result: Dose-dependently inhibited A2780-SP cell proliferation. Cell Migration Assay Cell line: U-87 MG human glioblastoma cells. Concentration: 10 μM, 50 μM, 100 μM, 200 μM. Incubation time: 24 h, 48 h, 72 h. Result: Significantly impeded gap closure, with the most effective inhibition observed at 200 μM for all time points after 24, 48, and 72 h of incubation. Apoptosis Analysis Cell line: A2780-SP cells. Concentration: 1 μM, 10 μM. Incubation time: 24 h. Result: Induced G0/G1 arrest and significantly increased the population of AV+/PI+ cells at concentrations over 1 μM. Western blot analysis. Cell line: A2780-SP cells. Concentration: 1 μM, 10 μM. Incubation time: 24 h. Result: Especially reduced OCT3/4 and SOX2 protein expression related to stemness and ERK phosphorylation related to cell growth, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Polibutin | Modulon | Dromostat | EINECS 251-845-9 | Ibutin | Polibutin | TM 906 | Trimebutine maleate, Trimedat

Quick Database Links

Gene Symbol

Calcium Channel