TRIM33 (C2) Antibody, Rabbit Polyclonal

SKU: orb67253

Description

Rabbit polyclonal to TRIM33.Tripartite motif-containing protein 33 (TRIM33) is a nuclear protein localized in discrete nuclear dotsresembling nuclear bodies. TRIM33 acts as an E3 ubiquitin-protein ligase, and promotes SMAD4ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. TRIM33 mayact as a transcriptional repressor of the TGF-beta/BMP signaling cascade. It is thought that TRIM33can monoubiquitinate SMAD4, which hampers its ability to form a stable complex with activatedSMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. TRIM33 plays a role in thecontrol of cell proliferation. Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC).

Research Area

Epigenetics

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human TRIM33
• Molecular Weight: 123
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-TRIM33 antibody,anti-E3 ubiquitinprotein ligase TRIM33 antibody,anti-Ectodermin homolog antibody,anti-RETfused gene 7 protein antibody,anti-Protein Rfg7 antibody,anti- Transcription intermediary factor 1gamma antibody,anti-TIF1gamma antibody,anti-Tripartite motifcontaining protein 33 antibody

Quick Database Links

UniProt

Q9UPN9