Triglycidyl isocyanurate

SKU: orb1305919

Description

Triglycidyl isocyanurate (Teroxirone) is a DNA-alkylating triepoxide with antineoplastic properties, demonstrated to inhibit non-small cell lung cancer cell growth in vitro by activating p53 and inducing apoptosis. It also finds industrial application as a cross-linking agent in polyester powder coatings for metal finishing.

Research Area

Cell Biology

Key Properties

• CAS Number: 2451-62-9
• MW: 297.26
• Purity: 99.01%
• Formula: C₁₂H₁₅N₃O₆
• SMILES: C(N1C(=O)N(CC2CO2)C(=O)N(CC3CO3)C1=O)C4CO4
• Target: MDM-2/p53,Apoptosis
• Solubility: DMSO:50 mg/mL (168.2 mM)

Bioactivity

• In Vivo:
  Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2-3 days for a total of seven doses over 30 days) suppresses xenograft tumor growth without affecting weight in nude mice.
• In Vitro:
  Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres. Triglycidyl isocyanurate (0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.
• Cell Research:
  Triglycidyl isocyanurate (0-30 μM; 48 hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres.
• Animal Research:
  Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TGI, TGIC, Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, Triglycidyl isocyanurate, tumor, NSCLC, inhibit, liver cancer, p53, p53-MDM2, Inhibitor, hepatocellular, Hep3B, HepG2, HCC, MDM-2/p53, DNA synthesis, carcinoma, Apoptosis, anticancer agent

Compound Identifiers

PubChem CID

17142