Triglycidyl isocyanurate

SKU: orb1940392

Description

Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.(In Vitro):Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres. Triglycidyl isocyanurate (0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.(In Vivo):Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice.

Key Properties

• CAS Number: 2451-62-9
• MW: 297.267
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₅N₃O₆
• SMILES: O=c1n(CC2CO2)c(=O)n(CC2CO2)c(=O)n1CC1CO1
• Target: Apoptosis
• Solubility: In Vitro: DMSO : 50 mg/mL (168.20 mM)

Bioactivity

• In Vivo:
  Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice. Animal model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area. Dosage: 1.8 mg/kg and 3.6 mg/kg. Administration: Subcutaneous injection; every 2–3 days for total seven times; 30 days. Result: Inhibited the growth of xenograft tumors.
• In Vitro:
  Triglycidyl isocyanurate(0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells. Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres. Cell Viability Assay Cell line: A549, H460 and H1299 cells. Concentration: 0 μM; 5 μM; 10 μM; 30 μM. Incubation time: 48 hours. Result: Inhibited tumor cells growth in soft agar. Western blot analysis. Cell line: A549, H460 and H1299 cells. Concentration: 0 μM; 5 μM; 10 μM; 30 μM. Incubation time: 48 hours. Result: Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tris(2,3-epoxypropyl) Isocyanurate | TGI | TGIC | Teroxirone

Quick Database Links

Gene Symbol

Apoptosis