Triclocarban

SKU: orb1302805

Description

Triclocarban is an antimicrobial compound historically used in personal care products. It serves as a research chemical for studying its mechanisms, environmental persistence, and biological effects in both in vitro assays and in vivo toxicological models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 101-20-2
• MW: 315.58
• Purity: 99.42% (May vary between batches)
• Formula: C₁₃H₉Cl₃N₂O
• SMILES: ClC1=CC=C(NC(=O)NC2=CC(Cl)=C(Cl)C=C2)C=C1
• Target: Antibacterial
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (6.34 mM);DMSO:45 mg/mL (142.59 mM)

Bioactivity

• In Vivo:
  Triclocarban, when used in soap during showering, is significantly absorbed by humans, with its peak concentration (Cmax) in whole blood ranging between 23 nM and 530 nM. While exposure to triclocarban during pregnancy does not impact the viability of pregnancy, exposure during lactation adversely affects offspring survival.
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• In Vitro:
  Triclocarban (300 nM) enhances the cytotoxicity of 300 μM H2O2 in rat thymocytes without independently increasing cell death, facilitating H2O2-induced cell death and hence elevating the dead cell population . It exhibits estrogenic activities by inducing luciferase in an ER reporter assay, promoting MCF-7 cell proliferation, up-regulating pS2, and down-regulating ERα at mRNA and protein levels in MCF-7 cells .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cleaning, Cutisan, Bacterial, antimicrobial, 3,4,4′-Trichlorocarbanilide, endocrine-disrupting, Inhibitor, inhibit, personal, Procutene, Solubacter, products, Triclocarban

Compound Identifiers

PubChem CID

7547