Triclocarban

SKU: orb1222930

Description

Triclocarban, an antimicrobial agent, is used in personal cleaning products.(In Vitro):Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.(In Vivo):Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 101-20-2
• MW: 315.58
• Purity: >98% (HPLC)
• Formula: C₁₃H₉Cl₃N₂O
• SMILES: Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1
• Target: Androgen Receptor (AR)
• Solubility: DMSO : ≥ 150 mg/mL; 475.32 mM

Bioactivity

• In Vivo:
  Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of off spring.
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• In Vitro:
  Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,4,4′-Trichlorocarbanilide

Quick Database Links

Gene Symbol

Androgen Receptor (AR)