TREM2 agonist-2

SKU: orb1687293

Description

TREM2 agonist-2 (I-192) is a potent, orally bioavailable small molecule activator of Triggering Receptor Expressed on Myeloid cells 2. It is a valuable research tool for investigating TREM2 pathway biology in models of neurodegenerative diseases, including Alzheimer's disease, in both cellular and animal studies.

Research Area

Neuroscience; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2738485-98-6
• MW: 451.92
• Purity: >99.99% (May vary between batches)
• Formula: C₂₄H₂₃ClFN₅O
• SMILES: CC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5
• Target: Others
• Solubility: DMSO:257.5 mg/mL (569.79 mM)

Bioactivity

• Target IC50:
  hTREM2 (HEK293 cells):< 0.05 μM (EC50)
• In Vivo:
  The results indicate that TREM2 agonist-2 (50 mg/kg; twice daily; oral gavage for one day) can bind to the TREM2 target, which can interact with microglial cells.
• In Vitro:
  Treatment with TREM2 agonist-2 (0-100μM; 16 hours) activated hTREM2 in HEK293 cells, with an EC50 value less than 0.05μM for cell viability assay.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TREM2

Compound Identifiers

PubChem CID

165412595