Rel-TREM2 agonist-2

SKU: orb1819242

Description

Rel-TREM2 agonist-2 is a potent small molecule agonist of the TREM2 receptor, exhibiting a half-maximal activity concentration (C50) of ≤0.05 µM and a maximal effect (E.max) exceeding 250 µM. This compound is a valuable research tool for investigating TREM2 signaling in vitro and exploring its therapeutic potential in neurodegenerative disease models such as Alzheimer's in vivo.

Key Properties

• CAS Number: 2738485-99-7
• MW: 451.92
• Purity: >99.99% (May vary between batches)
• Formula: C₂₄H₂₃ClFN₅O
• SMILES: CC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5
• Target: Others
• Solubility: DMSO:55 mg/mL (121.7 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

rel5(4Chloro2fluorophenyl)2,3dimethyl7[(2R,4S)tetrahydro2(1methyl1Hpyrazol4yl)2Hpyran4yl]pyrido[3,4b]pyrazine

Compound Identifiers

PubChem CID

165412595