Travoprost

SKU: orb1220626

Description

Travoprost is used to treat glaucoma and ocular hypertensionis a potent and selective FP prostaglandin receptor agonist.(In Vitro):Travoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.(In Vivo):Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 157283-68-6
• MW: 500.55
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₅F₃O₆
• SMILES: CC(C)OC(=O)CCC\C=C/CC1C(O)CC(O)C1\C=C\C(O)COc1cccc(c1)C(F)(F)F
• Target: Prostaglandin Receptor
• Solubility: DMSO:41.67 mg/mL (83.25 mM)

Bioactivity

• In Vivo:
  Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b. i. d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.
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• In Vitro:
  Travoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fluprostenol isopropyl ester | AL6221 | Flu-Ipr

Quick Database Links

Gene Symbol

Prostaglandin Receptor