(+)-Fluprostenol

SKU: orb1306434

Description

(+)-Fluprostenol (AL-5848) is a synthetic prostaglandin F2α analog and a potent PTGFR agonist. It is utilized in research to study reproductive biology, as it downregulates Oviductal glycoprotein 1 (OVGP1) expression. This compound is applied in both in vitro and in vivo models to investigate uterine and ovarian function.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54276-17-4
• MW: 458.47
• Purity: 97.35% (May vary between batches)
• Formula: C₂₃H₂₉F₃O₆
• SMILES: O[C@@H](COc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
• Target: Prostaglandin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (17.45 mM);DMSO:325 mg/mL (708.88 mM)

Bioactivity

• In Vivo:
  (+)-Fluprostenol(s.c. to rats on day 18 of pregnancy) increased cervical creep, or softness, by the following day. Doses of (+)-Fluprostenol 100-fold larger were necessary to increase uterine contractions. (+)-Fluprostenol produced falls in serum progesterone concentrations, increases in 20 alpha-dihydroprogesterone concentrations, no changes in oestradiol or relaxin concentrations and a reduction in the ovarian human chorionic gonadotrophin binding capacity in vitro. (+)-Fluprostenol was less potent in inducing cervical softness when administered per vaginam, and a dose which produced softening in pregnant rats was ineffective in ovariectomized steroid-maintained pregnant or pro-oestrous rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fluprostenol,, Fluprostenol, (+)-, Fluprostenol, Inhibitor, inhibit, (+)Fluprostenol, (+)-Fluprostenol, (+) Fluprostenol, AL 5848, AL5848, AL-5848, Travoprost acid, PTGER2, ProstaglandinReceptor, prostaglandin F2α, Prostaglandin Receptor, OVGP1, Oviductal glycoprotein 1

Compound Identifiers

PubChem CID

5311100