Trastuzumab deruxtecan Antibody

SKU: orb1985029

Description

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, delivering a potent topoisomerase I inhibitor payload. It demonstrates significant antitumor activity in HER2-positive cancers, supported by in vitro cytotoxicity assays and in vivo xenograft models for breast and gastric cancer research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1826843-81-5
• MW: 145 kDa (average)
• Purity: 95.00%
• Target: EGFR,Antibody-Drug Conjugates (ADCs)

Bioactivity

• Target IC50:
  Axl (KPL-4 cells):109.7 pM
• In Vivo:
  METHODS: Trastuzumab deruxtecan (T-DXd) (10 mg/kg, intravenous injection) was used to treat EMT6-hHER2 tumor-bearing mice, and the changes in tumors in the mice were observed. RESULTS: Trastuzumab deruxtecan significantly inhibited tumor growth in EMT6-hHER2 tumor-bearing mice 18 days after treatment.
• In Vitro:
  METHODS: HER2-positive KPL-4 cells were treated with Trastuzumab deruxtecan (T-DXd) (1 pM-10 nM, 5 days) and cell viability was calculated. RESULTS: Trastuzumab deruxtecan can inhibit the growth of HER2-positive KPL-4 cells with an IC50 value of 109.7 pM. METHODS: Trastuzumab deruxtecan (10 nM, 5 days) was used to treat co-cultured HER2-positive KPL-4 cells and HER2-negative MDA-MB-468 cells, and the number of viable cells was measured to determine whether it induced bystander killing. RESULTS: Trastuzumab deruxtecan killed both KPL-4 and MDA-MB-468 cells.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADCs, ADC Antibody, AntibodyDrug Conjugates (ADCs), Antibody-Drug Conjugates, AntibodyDrugConjugates, AntibodyDrugConjugates(ADCs), DS-8201a, DS 8201, T-DXd, VRN-101099, Trastuzumab deruxtecan

Quick Database Links

Gene Symbol

EGFR,Antibody-Drug Conjugates (ADCs)