trans-Ferulic acid

SKU: orb1220819

Description

Trans-Ferulic acid causes the phosphorylation of β-catenin resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.trans-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

Key Properties

• CAS Number: 537-98-4
• MW: 194.18
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₀O₄?
• SMILES: COc1cc(\C=C\C(O)=O)ccc1O
• Target: Bcl-2
• Solubility: In Vitro: DMSO : 100 mg/mL (514.99 mM)

Bioactivity

• In Vivo:
  Animal model: Male Wister Albino Rat model. Dosage: 100 mg/kg. Administration: i. g, once a day for 21 days. Result: Decreased tamoxifen-induced elevated enzyme activities of AST, ALT, and ALP and ameliorated the decrease in the hepatic enzyme activities.
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• In Vitro:
  Cell Proliferation Assay Cell line: H1299. Concentration: 0.03-0.6 mM Incubation time: 24 h, 48 h. Result: Low dose had no significant cytotoxic effect, but cytotoxicity was observed with 0.3 and 0.6 mM for 48 h. Apoptosis Analysis Cell line: H1299. Concentration: 0.03-0.6 mM Incubation time: 48 h. Result: Caused the arrest of the cell cycle at G0/G1 and a decrease in the percentage of the G2/M phase. And induced a significant increase in apoptotic populations. with 0.6 mM Cell Migration Assay Cell line: H1299. Concentration: 0.03-0.6 mM Incubation time: 16 h, (48 h). Result: Inhibited cell migration and invasion. by reducing the activity of MMP 2 and MMP 9 and increased β-catenin phosphorylation at Thr41/Ser45 but did not affect β-catenin protein levels.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(E)-Coniferic acid

Quick Database Links

Gene Symbol

Bcl-2