Tradipitant

SKU: orb1940686

Description

Tradipitant is an antagonist of neurokinin-1.(In Vitro):Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus .(In Vivo):Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands .

Key Properties

• CAS Number: 622370-35-8
• MW: 587.91
• Purity: >98% (HPLC)
• Formula: C₂₈H₁₆ClF₆N₅O
• SMILES: FC(F)(F)c1cc(Cn2nnc(c2-c2ccncc2)-c2ncccc2C(=O)c2ccccc2Cl)cc(c1)C(F)(F)F
• Target: Neurokinin Receptor
• Solubility: In Vitro: DMSO : 100 mg/mL (170.10 mM)

Bioactivity

• In Vivo:
  Autoradiography experiments reveal that intravenously administered Tradipitant ([3H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands.
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• In Vitro:
  Results reveal that Tradipitant ([3H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal).
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VLY-686 | LY686017

Quick Database Links

Gene Symbol

Neurokinin Receptor