Tradipitant

SKU: orb1307652

Description

Tradipitant

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 622370-35-8
• MW: 587.9
• Purity: 99.42% (May vary between batches)
• Formula: C₂₈H₁₆ClF₆N₅O
• SMILES: FC(F)(F)c1cc(Cn2nnc(c2-c2ccncc2)-c2ncccc2C(=O)c2ccccc2Cl)cc(c1)C(F)(F)F
• Target: Neurokinin receptor
• Solubility: DMSO:60 mg/mL (102.06 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (4.25 mM)

Bioactivity

• In Vivo:
  Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands .
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• In Vitro:
  Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Neurokininreceptor, Neurokinin Receptor, Neurokinin receptor, NK receptor, NK1, NK-1, LY 686017, LY686017, LY-686017, inhibit, Tachykinin receptor, Tradipitant, VLY 686, VLY686, VLY-686

Compound Identifiers

PubChem CID

9916461