Tozorakimab Antibody

SKU: orb1980472

Description

Tozorakimab (MEDI-3506) is a human IgG1 monoclonal antibody that neutralizes IL-33, blocking its signaling via the ST2 and RAGE/EGFR receptors. This inhibition reduces inflammatory responses and epithelial dysfunction, making it a valuable research tool for investigating COPD pathogenesis in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2376858-66-9
• MW: 144.41 kDa
• Purity: SEC-HPLC：96.03%
• Target: Interleukin,Others

Bioactivity

• Target IC50:
  IL-33:0.082 nM
• In Vivo:
  Female humanized IL-33 mice (6–10 weeks of age) were anaesthetized using isoflurane. Prophylactic intraperitoneal administration of Tozorakimab (0.1, 1.0, 3.0 and 10.0 mg/kg) dose-dependently inhibited IL-5 levels in bronchoalveolar lavage fluid (BALF) compared with the controls.
• In Vitro:
  Tozorakimab had a > 10,000-fold higher potency for IL-33red than the lead mAb (33v20064) in a biochemical epitope competition assay (IC50=0.082 nM).

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MEDI 3506, MEDI3506, MEDI-3506

Quick Database Links

Gene Symbol

Interleukin,Others