Topovale

SKU: orb1298379

Description

Topovale (ARC111) is a potent topoisomerase I inhibitor that suppresses hypoxia-induced HIF-1α accumulation. It demonstrates low nanomolar cytotoxicity against various cancer cell lines, with activity shown to be dependent on functional topoisomerase I in comparative in vitro studies using sensitive and resistant cell models.

Research Area

Molecular Biology

Key Properties

• CAS Number: 500214-53-9
• MW: 421.45
• Purity: 99.94% (May vary between batches)
• Formula: C₂₃H₂₃N₃O₅
• SMILES: C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5
• Target: Topoisomerase
• Solubility: DMSO:Insoluble

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARC111, ARC-111, ARC 111, topoisomerase I, Topoval, Topovale

Compound Identifiers

PubChem CID

9888428