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Topovale

SKU: orb1298379

Description

Topovale (ARC111) is a potent topoisomerase I inhibitor that suppresses hypoxia-induced HIF-1α accumulation. It demonstrates low nanomolar cytotoxicity against various cancer cell lines, with activity shown to be dependent on functional topoisomerase I in comparative in vitro studies using sensitive and resistant cell models.

Research Area

Molecular Biology

Images & Validation

Key Properties

CAS Number500214-53-9
MW421.45
Purity99.94% (May vary between batches)
FormulaC23H23N3O5
SMILESC(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5
TargetTopoisomerase
SolubilityDMSO:Insoluble

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ARC111, ARC-111, ARC 111, topoisomerase I, Topoval, Topovale

Similar Products

  • Topovale [orb1217968]

    >98% (HPLC)

    500214-53-9

    421.45

    C23H23N3O5

    1 g, 500 mg, 200 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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Key Properties

No computed properties available.

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Topovale (orb1298379)

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Available Sizes

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1 mg
$ 130.00
5 mg
$ 220.00
10 mg
$ 300.00
25 mg
$ 500.00
50 mg
$ 720.00
100 mg
$ 1,010.00
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