Topovale

SKU: orb1217968

Description

Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.

Key Properties

• CAS Number: 500214-53-9
• MW: 421.45
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₃N₃O₅
• SMILES: COC1=C(OC)C=C(C(N(CCN(C)C)C2=C3C=NC4=C2C=C(OCO5)C5=C4)=O)C3=C1
• Target: Topoisomerase
• Solubility: DMSO:10 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Topoval | ARC 111 | ARC111 | ARC-111

Quick Database Links

Gene Symbol

Topoisomerase