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Topovale

SKU: orb1217968

Description

Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.

Images & Validation

Key Properties

CAS Number500214-53-9
MW421.45
Purity>98% (HPLC)
FormulaC23H23N3O5
SMILESCOC1=C(OC)C=C(C(N(CCN(C)C)C2=C3C=NC4=C2C=C(OCO5)C5=C4)=O)C3=C1
TargetTopoisomerase
SolubilityDMSO:10 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Topoval | ARC 111 | ARC111 | ARC-111

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  • Topovale [orb1298379]

    99.94% (May vary between batches)

    500214-53-9

    421.45

    C23H23N3O5

    50 mg, 100 mg, 1 mg, 5 mg, 10 mg, 25 mg
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Topovale (orb1217968)

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Available Sizes

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200 mg
500 mg
5 mg
$ 260.00
10 mg
$ 360.00
25 mg
$ 620.00
50 mg
$ 890.00
100 mg
$ 1,260.00