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Topoisomerase I inhibitor 17

SKU: orb2814122

Description

Topoisomerase I inhibitor 17 (Compound 7h) is a small molecule that induces Top1-mediated DNA damage and ROS, leading to apoptosis and G2/M arrest. It effectively inhibits colorectal cancer cell proliferation, migration, and tumor growth in PDX models, making it a valuable tool for oncology research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2413582-45-1
MW516.47
FormulaC28H21FN2O7
SMILESO(C)C=1C=C(C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=CC7=C(C6)OCO7)C=CC1F
TargetDNA/RNA Synthesis,Topoisomerase,Reactive Oxygen Species,Survivin,IAP,Bcl-2 Family,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information