Topiramate

SKU: orb1310396

Description

Topiramate

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 97240-79-4
• MW: 339.36
• Purity: 99.79%
• Formula: C₁₂H₂₁NO₈S
• SMILES: CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
• Target: iGluR,Potassium Channel,Carbonic Anhydrase,GABA Receptor,Calcium Channel,Sodium Channel,GluR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);Ethanol:33.9 mg/mL (99.89 mM);DMSO:55 mg/mL (162.07 mM)

Bioactivity

• In Vivo:
  In whole-cell voltage-clamp recordings from principal neurons of the basolateral nucleus of the rat amygdala, low concentrations of Topiramate selectively inhibit excitatory postsynaptic currents (EPSCs) mediated by pharmacologically isolated kainate receptors that contain the GluR5 subunit. Topiramate also noticeably reduces AMPA receptor-mediated EPSCs, albeit with less potency. Additionally, Topiramate slightly inhibits the sustained component of Na+ currents in isolated neurons, and after blocking Ca2+ and K+ currents, diminishes the peak of Na+-dependent persistent action potentials induced in layer V pyramidal neurons. The compound selectively inhibits synaptic responses mediated by the GluR5 kainate receptor. Moreover, Topiramate impedes the action of voltage-sensitive Na+ channels and non-N-methyl-D-aspartate receptors, while potentiating inhibition mediated by gamma-aminobutyric acid (GABA).
• In Vitro:
  Intraperitoneal injection of 20 and 40 mg/kg topiramate demonstrated a dose-dependent inhibition of both tonic convulsions and absence seizures. Intraperitoneal administration of topiramate at doses ranging from 25-100 mg/kg dose-dependently increased the threshold for pentylenetetrazol (PTZ)-induced clonic seizures. Topiramate was dose-effectively potent in suppressing acute seizures induced by perinatal hypoxia, with an ED50 of 2.1 mg/kg. Additionally, in DBA/2 mice, topiramate inhibited audiogenic seizures, confirming its anticonvulsant efficacy.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ca channels, CalciumChannel, Calcium Channel, Ca2+ channels, Carbonate dehydratase, Carbonic anhydrase, Carbonic Anhydrase, CarbonicAnhydrase, KcsA, Ionotropic glutamate receptors, inhibit, Na channels, Na+ channels, mGluR5, McN4853, McN-4853, McN 4853, iGluR, Inhibitor, GABAR, GABAReceptor, GABA Receptor, Gamma-aminobutyric acid Receptor, SodiumChannel, Sodium Channel, RWJ 17021, RWJ17021, RWJ-17021, Topiramate, PotassiumChannel, Potassium Channel, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

5284627