Topiramate

SKU: orb1223497

Description

Topiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson & Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved for, and now most frequently prescribed for, the prevention of migraines. A combination product containing phentermine and topiramate extended-release called QSYMIA is indicated for the management of obesity. (In Vitro):Topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 97240-79-4
• MW: 339.36
• Purity: >98% (HPLC)
• Formula: C₁₂H₂₁NO₈S
• SMILES: CC1(O[C@H]([C@@H](CO[C@@]2(COS(=O)(N)=O)O3)O1)[C@@H]2OC3(C)C)C
• Target: Carbonic Anhydrase
• Solubility: Ethanol: 68 mg/mL (200.37 mM); DMSO: 68 mg/mL (200.37 mM)

Bioactivity

• In Vitro:
  Topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

McN 4853 | RWJ 17021 | TPM

Quick Database Links

Gene Symbol

Carbonic Anhydrase