Tomatidine

SKU: orb1297652

Description

Tomatidine

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 77-59-8
• MW: 415.65
• Purity: 98.38% (May vary between batches)
• Formula: C₂₇H₄₅NO₂
• SMILES: CC1C2C(CC3C4CCC5CC(O)CCC5(C)C4CCC23C)OC11CCC(C)CN1
• Target: Autophagy,JNK,Endogenous Metabolite,NF-κB
• Solubility: DMSO:2.86 mg/mL (6.88 mM);0.1 M HCL:< 1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. METHODS AND RESULTS: We have recently demonstrated that Tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, Tomatidine has shown antibiotic activity against small-colony variants of S. aureus. CONCLUSIONS: We herein report the first study of the structure-activity relationship of Tomatidine against S. aureus.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Autophagy, Akt, Inhibitor, LDL, ERK, Endogenous Metabolite, mTOR, JNK, inhibit, MMP, NFκB, NFkB, NF-kB, NF-κB, Nuclear factor-kappaB, Nuclear factor-κB, PI3K, Tomatidine

Compound Identifiers

PubChem CID

312827