TOMATIDINE HYDROCHLORIDE

SKU: orb1221951

Description

Tomatidine hydrochloride is a potent inhibitor of Staphylococcus aureus small-colony variants, and also indirectly inhibits iNOS and COX-2 pathways.

Key Properties

• CAS Number: 6192-62-7
• MW: 452.11
• Purity: >98% (HPLC)
• Formula: C₂₇H₄₆ClNO₂
• SMILES: Cl.C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@]11CC[C@H](C)CN1
• Target: GluR
• Solubility: In Vitro: DMSO : 5 mg/mL (11.06 mMult)

Bioactivity

• In Vitro:
  Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tomatidine hydrochloride | Tomatidine HCl

Quick Database Links

Gene Symbol

GluR