TNF-α Antagonist

SKU: orb1694013

Description

This exocyclic peptide TNF-α antagonist mimics the TNFRI binding site, blocking TNF-α and RANK signaling to inhibit osteoclast activation. It is a research tool used in vitro and in vivo to study inflammatory bone resorption in models of rheumatoid arthritis and systemic bone loss.

Research Area

Cell Biology, Immunology & Inflammation; Pharmacology & Drug Discovery

Key Properties

• Target: TNF
• CAS Number: 199999-60-5
• MW: 1226.39
• Formula: C₅₈H₇₁N₁₁O₁₅S₂
• SMILES: CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16134442