NOD2 antagonist 1

SKU: orb1686954

Description

NOD2 antagonist 1 (compound 32) is a selective small molecule inhibitor of NOD2 with an IC50 of 5.23 µM. It effectively suppresses MDP-induced IL-8 secretion in THP-1 cells and inhibits the production of IL-6, IL-10, and TNF-α in PBMCs, making it a useful tool for studying NOD2-mediated inflammatory pathways in vitro.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2411441-54-6
• MW: 474.57
• Purity: 98.83% (May vary between batches)
• Formula: C₂₆H₂₆N₄O₃S
• SMILES: O=C(NC1=CC=C2C(=C1)CCC2)CN3C=4C=CC=CC4N=C3CCNS(=O)(=O)C=5C=CC=CC5
• Target: NOD

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162672282