TMPyP4 tosylate

SKU: orb1940762

Description

TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.

Key Properties

• CAS Number: 36951-72-1
• MW: 1363.6
• Purity: >98% (HPLC)
• Formula: C₇₂H₆₆N₈O₁₂S₄
• SMILES: Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc1[nH]2
• Target: DNA/RNA Synthesis
• Solubility: In Vitro: DMSO : 10 mg/mL (7.33 mM)

Bioactivity

• In Vivo:
  Animal model: MX-1 mammary chemoadjuvant model. Dosage: 10 and 20 mg/kg. Administration: Intraperitoneal injection (i.p.), twice weekly. Result: Inhibited tumor growth and prolonged mice survival. Animal model: SARS-CoV-2-infected hamster. Dosage: 15 mg/kg or 30 mg/kg. Administration: i. n. , starting at 1 h prior to virus inoculation and continuing until 3 days post infection. Result: Decreased the mean viral loads in the nasal wash, nasal turbinate and lung tissues.
• In Vitro:
  Cell Viability Assay Cell line: HOS cells. Concentration: 50 μM. Incubation time: 48 or 96 h. Result: Time-dependently inhibited cell viability. Western blot analysis. Cell line: K562 cells. Concentration: 100 μM. Incubation time: 24 or 48 h. Result: Increased the expression of p21CIP1 protein and p57KIP2 protein.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TMP 1363

Quick Database Links

Gene Symbol

DNA/RNA Synthesis