TMP195

SKU: orb1303477

Description

TMP195 is a potent and selective inhibitor targeting class IIa histone deacetylases (HDACs). This research compound is utilized in vitro and in vivo to investigate epigenetic mechanisms in areas such as cancer, metabolism, and immune function.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1314891-22-9
• MW: 456.42
• Purity: 98.66% (May vary between batches)
• Formula: C₂₃H₁₉F₃N₄O₃
• SMILES: CC(C)(CNC(=O)c1cccc(c1)-c1noc(n1)C(F)(F)F)c1coc(n1)-c1ccccc1
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.48 mM);DMSO:82 mg/mL (179.66 mM)

Bioactivity

• Target IC50:
  HDAC6:47800 nM|HDAC8:11700 nM|HDAC9:15 nM(Ki)|HDAC5:60 nM(Ki)|HDAC7:26 nM(Ki)|HDAC4:59 nM(Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone deacetylases, HDAC, HDAC7, HDAC9, HDAC4, HDAC5, inhibit, Inhibitor, TFMO 2, TFMO2, TFMO-2, TMP195, TMP-195, TMP 195

Compound Identifiers

PubChem CID

67324851