TMP-195

SKU: orb1226563

Description

A first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively; shows no significant inhibition for others HDACs; alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes in mice; induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours.

Key Properties

• CAS Number: 1314891-22-9
• MW: 456.42
• Purity: >98% (HPLC)
• Formula: C₂₃H₁₉F₃N₄O₃
• SMILES: O=C(NCC(C1=COC(C2=CC=CC=C2)=N1)(C)C)C3=CC=CC(C4=NOC(C(F)(F)F)=N4)=C3
• Target: HDAC
• Solubility: DMSO: 82 mg/mL (179.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TMP 195 | TMP195

Quick Database Links

Gene Symbol

HDAC