TLR4-IN-C34

SKU: orb1220235

Description

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 40592-88-9
• MW: 389.4
• Purity: >98% (HPLC)
• Formula: C??H??NO?
• SMILES: O=C(N[C@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)[C@H]1OC(C)C)C
• Target: TLR
• Solubility: DMSO : 250 mg/mL (642.01 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa. Animal model: Experimental NEC induced in 7-8 day old mice. Dosage: 1 mg/kg. Administration: Orally every morning. Result: Attenuated intestinal inflammation.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR