TLR4-IN-C34

SKU: orb1298877

Description

TLR4-IN-C34 is a selective Toll-like receptor 4 (TLR4) antagonist. It has demonstrated efficacy in reducing systemic inflammation in preclinical models, including experimental endotoxemia and necrotizing enterocolitis, supporting its use in researching innate immunity and inflammatory diseases.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 40592-88-9
• MW: 389.4
• Purity: 99.77% (May vary between batches)
• Formula: C₁₇H₂₇NO₉
• SMILES: CC(C)O[C@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1NC(C)=O
• Target: TLR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM);DMSO:250 mg/mL (642.01 mM)

Bioactivity

• In Vitro:
  TLR4-IN-C34 reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
• Animal Research:
  Experimental NEC was induced in 7 8 day old mice .TLR4-IN-C34 was administered via the oral route at a concentration of 1 mg/kg on each morning of the four day model.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Toll-like Receptor (TLR), TLR4INC34, TLR-4-IN-C34, TLR4-IN-C34, TLR4 IN C34, TLR4, TLR

Compound Identifiers

PubChem CID

91691128