TJ191

SKU: orb1298367

Description

TJ191 is a selective small-molecule agent designed to target and eliminate malignant T-cell leukemia/lymphoma cells characterized by low expression of TβRIII. Its application in both in vitro and in vivo research models supports its investigation as a potential therapeutic strategy for specific T-cell malignancies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1522415-97-9
• MW: 255.38
• Purity: 99.95% (May vary between batches)
• Formula: C₁₃H₂₁NO₂S
• SMILES: CCCCCCCc1cc(C(=O)OC)c(N)s1
• Target: Apoptosis
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (9.79 mM);DMSO:55 mg/mL (215.37 mM)

Bioactivity

• In Vitro:
  TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h. TJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 μM) and MT-4 (IC50=47 ± 5 μM) cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MT-2, inhibit, JURKAT, PMBC, MOLT-3, MOLT-4, HSB-2, Inhibitor, Apoptosis, cancer, C8166, CEM, TJ191, TJ-191, TJ 191, SUP-T1

Compound Identifiers

PubChem CID

72704992