TJ191

SKU: orb1218758

Description

TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.

Key Properties

• CAS Number: 1522415-97-9
• MW: 255.38
• Purity: >98% (HPLC)
• Formula: C₁₃H₂₁NO₂S
• SMILES: CCCCCCCC1=CC(C(OC)=O)=C(N)S1
• Target: Apoptosis
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  TJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50 = 17±10 μM) and MT-4 (IC50 = 47 ± 5 μM) cells. TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h. Cell Viability Assay Cell line: Malignant T-cell leukemia/lymphoma cells. Concentration: 0.01 μM, 0.1 μM, 1 μM, 10 μM, 100 μM Incubation time: 24 hours. Result: Exhibited inhibitory effects in drug-sensitive cells with IC50 ranging 0.13 μM to 3.1 μM. Apoptosis Analysis Cell line: CEM cell line. Concentration: 0.1-3 μM Incubation time: 8 or 24 hours. Result: Led to cell apoptosis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis