Tipepidine hydrochloride

SKU: orb1309009

Description

Tipepidine hydrochloride is a reversible dopamine D2 receptor antagonist that inhibits associated GIRK channel currents (IC50 = 7.0 µM). This compound exhibits antidepressant-like effects in animal models and serves as a useful research tool for studying dopaminergic signaling and mood-related disorders in both in vitro and in vivo experimental systems.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1449686-84-3
• MW: 311.89
• Purity: 100.00%
• Formula: C₁₅H₁₈ClNS₂
• SMILES: Cl.CN1CCCC(C1)=C(c1cccs1)c1cccs1
• Target: Dopamine Receptor,Potassium Channel
• Solubility: DMSO:41.67 mg/mL (133.6 mM);H2O:50 mg/mL (160.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.41 mM)

Bioactivity

• Target IC50:
  D2:7.0 μM
• In Vivo:
  In ACTH-treated rats, Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test. In ACTH-treated rats, Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tipepidine, Tipepidine hydrochloride, Tipepidine Hydrochloride, PotassiumChannel, Potassium Channel, KcsA, inhibit, Inhibitor, dopamine D2 receptor, Dopamine Receptor, DopamineReceptor, D2

Compound Identifiers

PubChem CID

138991192