Tipepidine hydrochloride

SKU: orb1218798

Description

Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1449686-84-3
MW	311.89
Purity	>98% (HPLC)
Formula	C₁₅H₁₈ClNS₂
SMILES	CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
Target	Dopamine Receptor
Solubility	DMSO:41.67 mg/mL (133.60 mM; Need ultrasonic)

Bioactivity

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In Vivo	Animal model: Male Wistar rats weighting 150-240 g (5-7 weeks old). Dosage: 10, 20 and 40 mg/kg. Administration: i.p.; 0.5, 5, 23 hours. Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Dopamine Receptor

Protocol Information

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Purity:	>99.99% (May vary between batches)
CAS Number:	1449686-84-3
MW:	311.89
Formula:	C₁₅H₁₈ClNS₂