Ticlopidine

SKU: orb1223101

Description

Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.(In Vitro):Ticlopidine exhibits activity against human CD39 with apparent Ki,app values of 14 μM.Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12 μM.Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 μM) reducing its effect in the following days.(In Vivo):Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 55142-85-3
• MW: 263.78
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄ClNS
• SMILES: C1CN(Cc2c1scc2)Cc1ccccc1Cl
• Target: EGFR
• Solubility: In Vitro: DMSO : ≥ 100 mg/mL (379.09 mM)

Bioactivity

• In Vivo:
  Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver. Animal model: Male Sprague-Dawley rats (7-8 weeks old, weighing 270-300 g). Dosage: 4 or 10 mg/kg. Administration: Orally administered 30 min before oral administration of losartan. Result: The AUC and Cmax of Losartan after oral administration with Losartan and 10 mg/kg Ticlopidine were significantly greater (by 65.0% and 49.4%, respectively) than those of control rats.
• In Vitro:
  Ticlopidine exhibits activity against human CD39 with apparent Ki, app values of 14 μM. Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12 μM. Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 μM) reducing its effect in the following days. Cell Proliferation Assay Cell line: Human endothelial cells. Concentration: 30 and 150 μM. Incubation time: 2, 6; 10 days. Result: Treated cells grow slower if compared with controls and this effect correlates with the concentration of Ticlopidine in the culture medium.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR