Ticlopidine hydrochloride

SKU: orb1310688

Description

Ticlopidine hydrochloride is a potent antiplatelet agent used in research involving coronary stent placement. It is widely applied in cardiovascular disease studies, with established utility in both in vitro platelet aggregation assays and in vivo models of thrombosis.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53885-35-1
• MW: 300.25
• Purity: 99.98%
• Formula: C₁₄H₁₅Cl₂NS
• SMILES: Cl.Clc1ccccc1CN1CCc2c(C1)ccs2
• Target: Adenosine Receptor
• Solubility: H2O:30 mg/mL (99.92 mM);DMSO:65 mg/mL (216.49 mM)

Bioactivity

• Target IC50:
  P2 receptor:2 μM
• In Vivo:
  Ticlopidine HCl inhibits platelet aggregation by activating basal PGE1-induced cyclase activity, blocking the enhancement of cyclase activity induced by PGE2, thereby increasing platelet c-AMP levels, and suppressing prostaglandin synthesis from endogenous substrates. Additionally, it alters platelet membrane function and inhibits aggregation through the blockade of ADP receptors.
• In Vitro:
  Oral administration of Ticlopidine HCl in rats enhances the affinity of cyclase on platelet membranes for prostaglandin E1, subsequently activating both the basal and prostaglandin E1-stimulated without affecting the enzyme activity induced by adenosine or sodium fluoride. Ticlopidine HCl exhibits an inhibitory effect on platelet aggregation with an IC50 of 2 μM in males.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adenosine Receptor, AdenosineReceptor, inhibit, Inhibitor, P1 receptor, Ticlodix, Ticlodone, Ticlopidine, Ticlopidine HCl, Ticlopidine Hydrochloride, Ticlopidine hydrochloride

Compound Identifiers

PubChem CID

65335