Ticlopidine hydrochloride

SKU: orb1224752

Description

Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients’ WBC and platelets when they are taking ticlopidine.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53885-35-1
• MW: 300.25
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₅Cl₂NS
• SMILES: Cl.ClC1=CC=CC=C1CN1CCC2=C(C1)C=CS2
• Target: P2 Receptor
• Solubility: Ethanol: 1 mg/mL (3.33 mM); Water: 4 mg/mL (13.32 mM); DMSO: 1 mg/mL (3.33 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P2 Receptor