TICAM1 (N) Antibody, Rabbit Polyclonal

• Catalog Number: orb107116
• Category: Antibodies
• Description: Rabbit polyclonal to TICAM1. TIR domain-containing adapter molecule 1 (TICAM1) is Involved in innate immunity against invading pathogens. TICAM1 is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1; which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD, respectively. TICAM1 is ubiquitously expressed with higher levels observed in liver.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human, Mouse
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: N-terminal region of human TICAM1
• UniProt ID: Q8IUC6
• MW: 96
• Tested applications: WB
• Storage: -20°C
• Alternative names: anti TIR domain-containing adapter molecule 1 anti
• Note: For research use only

Western blot (WB) of total cell extracts from a. mouse thymus, b. human HeLa, c. human Jurkat; using anti-TICAM1 (N) (orb107116) at RT for 2 h.

IP-WB. Immunoprecipitation (IP) was performed with mouse thymus extracts with IgG or anti-TICAM1 (N) (orb107116), followed by WB with the same Ab.