TICAM1 (N) Antibody, Rabbit Polyclonal

SKU: orb107116

Description

Rabbit polyclonal to TICAM1. TIR domain-containing adapter molecule 1 (TICAM1) is Involved in innate immunity against invading pathogens. TICAM1 is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1; which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD, respectively. TICAM1 is ubiquitously expressed with higher levels observed in liver.

Images & Validation

• Tested Applications: WB
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human TICAM1
• Molecular Weight: 96
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti TIR domain-containing adapter molecule 1 antibody, anti TICAM-1 antibody, anti Proline-rich antibody, anti vinculin and TIR domain-containing protein B antibody, anti Putative NF-kappa-B-activating protein 502H antibody, anti PRVTIRB antibody, anti TRIF antibody, anti TRIP antibody

Western blot (WB) of total cell extracts from a. mouse thymus, b. human HeLa, c. human Jurkat; using anti-TICAM1 (N) (orb107116) at RT for 2 h.

IP-WB. Immunoprecipitation (IP) was performed with mouse thymus extracts with IgG or anti-TICAM1 (N) (orb107116), followed by WB with the same Ab.

Quick Database Links

UniProt

Q8IUC6