Thiostrepton

SKU: orb1226375

Description

Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.\n(In Vitro):Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A.(In Vivo):Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls.

Key Properties

• CAS Number: 1393-48-2
• MW: 1664.89
• Purity: >98% (HPLC)
• Formula: C₇₂H₈₅N₁₉O₁₈S₅
• SMILES: NC[S=N]H(C)C(O)=O
• Target: DNA/RNA Synthesis
• Solubility: DMSO: 40mg/mL

Bioactivity

• In Vivo:
  Animal model: Athymic (BALB/c nu/nu) nude mice bearing A4573 cells. Dosage: 17 mg/kg. Administration: Administered i.p. Result: Treatment inhibited the growth of EWS-derived tumors In vivo.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bryamycin | NSC 81722 | NSC 170365 | Thiactin | Thiostreptin A

Quick Database Links

Gene Symbol

DNA/RNA Synthesis